Cultural institutions and educational programs have a unique opportunity and an important obligation to promote human dignity and advocate for social justice. Since its inception 22 years ago, the Museum of Tolerance (MOT) has been in the forefront of redefining museums as catalysts for positive social change. Through cutting-edge technologies, interactive exhibits, compelling artifacts, dramatic multimedia displays and stimulating spaces, the MOT provides a unique immersive experience that brings the past to life, allows us to become witnesses to history, and puts a spotlight on the prejudice and discrimination that are still embedded in everyday society. The MOT engages our hearts and minds, challenging us to hold up a mirror and question our own closely held beliefs, attitudes and stigmas. It charges us to change the way we see the world and our role in it. The presentation will discuss the imperative for museums to address issues of access and inclusion for all audiences, regardless of their abilities and vulnerabilities, and illustrate specific examples at the MOT in preparing for and serving visitors with special needs. The MOT also plays a critical role in raising awareness for the general public about the realities of life experiences for people who have physical, emotional and intellectural disabilities. Our experience has taught us the real privilege of enabling and ennobling others, no matter how differently abled, to give of themselves and to empower them with the knowledge that they are appreciated for who they are.